For horizontal transmission, it has the chance to increases along with high-prevalence areas. It ended with greater variety of infection in family, and occur repeatedly in immigrants to developed countries.Immune response As a study that applied in twenty volunteers of adults, doctors took gastric biopsies two weeks after catching the infection by volunteers. They observed increasing in (Interlukin-1) IL-1, (Interlukin-8) IL-8, and (Interlukin-6) IL-6 because of stealth of lymphocytes and monocytes in gastric cavity. Then, anti- H. pylori, immunoglobulin IgM and IgG responses in infected serum. Four weeks since the infection happened, comparing with pre-infection, CD4+ and CD8+ T cells will present increasing in its levels. The procedure considered as an evidence that immune system has a rapid response to H. pylori infection. Symptoms In one hand, most doctors had the same theory about ulcer which is a result of H. pylori infection. This theory stands for, Commonly, the symptoms can be noticed between breastbones and naval region (umbilical region) as a burning pain and gnawing or stabbing. These symptoms including loss of appetite, nausea, and bleeding. Unfortunately, bleeding could cause anemia, fatigue, and weakness if it takes a long time while intensive bleeding manifests in viscera movements or vomiting with gloomy red blood. Usually, people feel the pain clearly in the early morning, between meals, and empty stomach. This feeling might remain for a couple of minute or even for days, and it can be removed by eating, drink milk, or taking antacids in some patients only. On the other hand, in 2015 a doctor David Hompes, who is a specialist in functional medicine, adopted the idea of symptoms are not bound in GI track only, but it is possible to affect other body’s part. Starting with Symptoms out of the GI track, neurological symptoms such as mood, brain function, memory, headache, feel tired weak, and lose focus. These symptoms occur due to Iron and B12 vitamin deficiency by reducing the amount of acid produced. This reduction occurs because H. pylori enters to the stomach tissue until it reaches the acid-cell producer and damage it. Besides, asthma, allergic symptoms and pain in muscle and joints. These happen because of immune system overactivation. Basically, as the bacteria will produce toxins, bunch of these toxins that the immune system will response to, will transfer along with undigested food molecules out of the body because of increasing the permeability in intestine. In addition, As the inflammation of stomach will spread around to the adjacent systems, cardiovascular system will be affected. Abnormal changing in sugar and insulin levels, increasing in blood pressure will display. Endocrine system will be affected as well by creating hormonal imbalances. Elevate stress by adrenal glands will impact other glands’ secretions such as sex hormone, thyroid hormones, and steroid hormones. Moving to symptoms in the GI track itself, As the bacteria are capable to affect any part of body, H. pylori associate with heartburn and acid reflux. It causes bleaching and burping because of reduction of acids in the same place that it exists in. Further, duodenal stomach ulcers or duodenal ulcers which could be worse and more serious if the following symptoms manifest: vomiting with blood, coffee like granules, dark tarry stool, rapid loos of weight. uncommonly, bad breath could be a sign for H. pylori as much as other diseases. Lastly, H. pylori can create bloating camps loose stools diarrhea and constitution. Treatment: As mentioned before that FDA has approved the first antibiotic in 1996. Since that approval, specialists work hardly to improve this one and create others that can be used for different patients. Based on the leap in pharmaceutical science, H. pylori treatment mainly depends on antibiotics that should be taken with another antibiotic or medication. It required taking two different antibiotics at once at least, aiming to prevent the bacteria resistance development to an appointed antibiotic. To get fully recover takes from ten to two days under taking effective antibiotics as metronidazole, clarithromycin, amoxicillin, or tetracycline (for those who are older than twelve years old) accompanied by ranitidine bismuth citrate, proton pump inhibitor, or bismuth subsalicylate. It will be recommended by doctors depending on patient’s history and situation. However, three main drugs under use until now that are Histamine H_2blockers, Proton pump inhibitors, and Bismuth subsalicylate. Histamine H_2 blockers activates acid manufacture by blocking a substance named histamine, as examples, Zantac (ranitidine), and Tagamet (cimetidine). Proton pump inhibitors use to diminish or even pause producing stomach acid, for example, Protonix (pantoprazole), Prevacid (lansoprazole), Prilosec (omeprazole), and Nexium (esomeprazole). Bismuth subsalicylate or Pepto-Bismol the main process presents in protecting the injured area from the acid by coating it. Usually, after four weeks and more, testing for H. pylori will be recommended by doctors just to ensure that the treatment works well. These medications improve antibiotics effectiveness against H. pylori in the surface. On the other side, the treatment could fail if two factors present which are patients non-obedience and antibiotics resistance. Also, follow a steady meal schedule especially for kids. Thus, their stomach does not be empty for long time. Substantially, it depends on having six small meals per day with having a break after each two meals. For children as well, parents must be cautious of giving them any medications result in stomach irritation or its bleeding such as aspirin-containing medicines and aspirin itself, anti-inflammatory drugs, and ibuprofen.Prevention: Because the absence of both infection prevention guidelines and vaccine against H. pylori, and little ambiguity of its transmission currently, make sure to follow steps in the diagram in order to prevent catching the infection easily. kids should be pressed to follow the steps more than adults. It backs to their durability and immune response. Conclusion: To sum up, H. pylori is a type of gram-negative bacteria infect stomach and effect other organs as well. Health care providers use to run four types of test: breath test or Carbon Isotope-urea test, blood test, stool test, and biopsy to indicate the presence of the bacteria. The infection either has familial transmission or due to contaminated environment. Burst feeding could inactivate the bacteria as some studies concluded. As any other disease infect the body, diverse symptoms will show up such as loss of appetite, nausea, bleeding, abnormal increasing in blood pressure and insulin levels. The last but not the least, the treatment differ based on patients’ situation and their history. Opportunely, it is possible to get rid of the infection after being caught by taking antibiotics and following a meal schedule especially for kids, or preventing its incidence by three main steps avoid both drinking contaminated water and pre-prepared food, and wash hands carefully. As the whole world is one company, I recommend especially all health care providers to be aware and avoid any cause to be infected for their health and their patients’. This recommendation for Parents as well to be in the safe side and to protect their children.